PP10 - EPIDEMIOLOGY AND CLINICAL CHARACTERISTIC OF LIVER CANCER CASES IN NORTH AND EAST PENINSULA OF MALAYSIA. #7

Mohamad Fadli Abd Rahman
Clinical Research Centre, Hospital Sultanah Bahiyah, Kedah, MALAYSIA

Nur Syuhada Adnan
Gastroenterology & Hepatology Unit, Department of Medicine, Hospital
Sultanah Nur Zahirah, Terengganu, MALAYSIA

Chan Huat Keat
Clinical Research Centre, Hospital Sultanah Bahiyah, Kedah, MALAYSIA

Muhammad Radzi Abu Hassan
Clinical Research Centre, Hospital Sultanah Bahiyah, Kedah, MALAYSIA

Objective(s): 
Hepatocellular carcinoma (HCC) is the 8th most common cancer in Malaysia. This study aimed to determine the epidemiological characteristics and clinical presentations of patients in a multiracial population in 2 different regions in Malaysia Peninsula. 

Methodology: 
Patients with HCC were retrospectively studied from 2009 to 2019. HCC was diagnosed principally on 3-Phasic computed tomography of the liver. The tumor was staged according to the Barcelona Clinic Liver Cancer (BCLC) classification.

Results:
Altogether, 171 patients were diagnosed with HCC. There were 113 (66.1%) Malay patients, 56 (32.7%) Chinese patients and 2 (1.2%) Indians, with the median of age 61 years and Male to Female ratio of 3.4:1. North Peninsula consist of 3 major racial background [Malay (n=87), Chinese (n=56), Indians (2)] whereas in East Peninsula all were Malays (n=26). The predominant etiology amongst patients was Viral Hepatitis (57.3%) and followed by Cryptogenic (29.8%) and Non-alcoholic steatohepatitis (6.4%). Most of HCC patients were cirrhotics (79.5%), Child-Turcotte-Pugh A 47.4% and BCLC staging was: Stage A (19.3%), Stage B (40.9%), Stage C (29.2%) and Stage D (10.53%), and predominantly Right Lobe disease (49.1%) followed by Both Lobe disease (30.9%). Almost 50% of patients still survive up to the review, with surgical resection and radiofrequency ablative therapy was carried out in 60 (57.5%) in Stage A patients and Transarterial chemoembolization in 23 (19.7%) with the remaining patients adopted refusal of therapy and palliation.

Discussion and Conclusions:
HCC is more common in Malays in this region particularly due to geographical racial distribution and Viral hepatitis is still the leading cause for HCC in Malaysia.